Solubilization of the New Generation Immunomodulator Fingolimod Using Natural, Modified, and Polymeric Cyclodextrins

Native, modified, and polymeric cyclodextrins are used for the first time to improve the solubility and bioavailability of synthetic immunomodulator fingolimod (FTY720). It is shown that the solubility of FTY720 grows in the presence of cyclodextrins. Constants of the stability of guest–host complexes and the index of efficiency of the solubilizing action of cyclodextrins are calculated from experimentally obtained phase solubility diagrams of FTY720. The effect the structure of cyclodextrin on the solubilization of FTY720 is considered.