Complexation of Baricitinib with β-Cyclodextrin and Its Dimeric Amino-Derivatives

A comparative study of the complexing and solubilizing capacity of β-cyclodextrin and its new dimeric diaminocationic derivatives in relation to baricitinib, a new generation immunomodulator, is performed. Isothermal saturation is used to determine the solubility of baricitinib in the presence of the considered β‑cyclodextrins in a phosphate buffer solution (pH 6.8). Thermodynamic parameters of complex formation are calculated, and a binding mode is proposed on the basis of 1H NMR data. The effect of the structure of β-cyclodextrin on the efficiency of complex formation and the solubilization of baricitinib is analyzed.