Calorimetric Determination of the Enthalpy of the Reaction of Formation of a Silver(I) Monocomplex with 1-Methyl-2-Mercaptoimidazole

The study of the reactivity of heterocyclic thioamides exhibiting antithyroid activity is of scientific and practical interest. For objective evaluation of the reactivity of thioamides with biologically active and biogenic metal ions, reliable thermodynamic parameters of complexation are of great importance. The thermodynamic parameters of complexation can be determined by various complementary methods, which increases the reliability of results. The thermodynamic parameters of the reaction of formation of a silver(I) monocomplex with 1-methyl-2-mercaptoimidazole (logK°, ∆rG°, ∆rH°, ∆rS°) were determined by isothermal titration calorimetry in water at T = 298.15 K. The results were compared with the thermodynamic parameters obtained previously by potentiometric titration using the temperature coefficient method to determine the enthalpy of complexation.