Calotropis procera: A Promising Candidate in Cancer Pharmacology

Calotropis procera, a plant belonging to the Asclepiadaceae family, with significant therapeutic potential. Indigenous to the arid regions of India, Africa, and China, Calotropis procera is recognized for its diverse biological activities, including anti-inflammatory, antimicrobial, hypoglycemic, and anticancer properties. This review focuses on the anticancer potential of Calotropis procera, highlighting its relevance in traditional medicine and its emerging role in modern therapeutic applications. Despite its promising medicinal value, Calotropis procera is also associated with toxicity, particularly its immunomodulatory effects, which can lead to severe conditions, such as delayed-type hypersensitivity and rheumatoid arthritis, if not managed properly. Plant taxonomy, widespread geographical distribution, and botanical characteristics are outlined, emphasizing its adaptability to various environments. Additionally, the traditional uses and folklore surrounding Calotropis procera are explored, illustrating its historical significance in treating ailments such as snake bites gynecological disorders and as a component in ritualistic practices. However, the potential risks associated with its use underscore the importance of careful application in therapeutic context. This review consolidates the existing knowledge on Calotropis procera, providing a foundation for further research into its mechanisms of action and potential as a pharmaceutical-grade treatment for cancer.