Texture analysis of T1- and T2-weighted images identifies myofiber atrophy and grip strength decline in streptozotocin-induced type 1 diabetic sarcopenia rats
Muscle texture analysis based on T<sub>1</sub>WI and T<sub>2</sub>WI effectively differentiated type 1 diabetic sarcopenic rats from normal controls and revealed strong associations with muscle strength and myofiber size. These findings indicate that MRI texture parameters serve as potential biomarkers for diagnosing muscle damage in type 1 diabetic sarcopenia patients, suggesting that MRI texture parameters are promising noninvasive tools for early detection and monitoring of myofiber atrophy in diabetic sarcopenia.
Authors
- Yunfei Zha (ORCID: https://orcid.org/0000-0002-8714-7472)
- Dong Xing
- Yufan Gao
- Fang Liu (ORCID: https://orcid.org/0000-0003-0972-9968)
- Ziyan Fei
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-02-11
- DOI
- https://doi.org/10.1186/s13018-025-05556-y
- Citations
- 2
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities