Dynamic Observation of Colonic Lesions, Commensal Microbiome, and Mycobiome Variations in Trinitrobenzene Sulfonic Acid-Induced Experimental Crohn’s Disease in Rats
Therefore, the data suggested that TNBS-induced CD can be roughly divided into two phases: the acute inflammatory phase (weeks 1-2) and the chronic inflammatory phase (weeks 3-5). However, the microbiome and mycobiome dysbiosis did not return to normal within the trial period. Hence, our findings may facilitate a better comprehension of the dynamic progress of experimental TNBS-induced CD.
Authors
- Mingjiang Liu (ORCID: https://orcid.org/0000-0002-1249-1164)
- Jingui Li (ORCID: https://orcid.org/0000-0001-6769-0200)
- Chenglong Yu (ORCID: https://orcid.org/0000-0002-0546-2779)
- Ruonan Bo
- Kai Fan (ORCID: https://orcid.org/0000-0002-7586-4896)
- Guian Fang
- Yuying Huai
- Junjie Huang (ORCID: https://orcid.org/0000-0003-2382-4443)
- Huiwen Wang (ORCID: https://orcid.org/0000-0003-4918-4659)
- Minxia Zhang (ORCID: https://orcid.org/0000-0002-3091-6285)
Institutions
- Shanghai CASB Biotechnology (China) (CN)
- Jiangsu Agri-animal Husbandry Vocational College (CN)
- China Agricultural University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Digestion
- Published
- 2025-02-11
- DOI
- https://doi.org/10.1159/000543337
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00