Association of Obesity With Sedative Dosing, Sedative Response, and Clinical Outcomes in Mechanically Ventilated Critically Ill Children
This study underscores the significance of accounting for body habitus when selecting and dosing opiates in children with acute respiratory failure. Obesity had substantial impact on medication exposure and clinical outcomes, particularly within a structured, protocolized sedation regimen. Further research is warranted to explore the intricate relationship between medication dosing and clinical outcomes in children with obesity.
Authors
- Lisa A. Asaro (ORCID: https://orcid.org/0000-0001-5736-0304)
- Martha A. Q. Curley (ORCID: https://orcid.org/0000-0001-5228-6694)
- Onella S. Dawkins-Henry (ORCID: https://orcid.org/0000-0003-0201-2913)
- David Wypij (ORCID: https://orcid.org/0000-0001-8367-8711)
- Shan L. Ward (ORCID: https://orcid.org/0000-0002-1375-6240)
Institutions
- Boston Children's Hospital (US)
- Apple (Israel) (IL)
- Children's Hospital of Philadelphia (US)
- Harvard University (US)
- UCSF Benioff Children's Hospital (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1097/cce.0000000000001214
- Citations
- 1
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.55