Single-cell and spatial-resolved profiling reveals cancer-associated fibroblast heterogeneity in colorectal cancer metabolic subtypes
Our study identified and described the potential protumor biological properties of SFRP2 + CAFs, and AGMAT may be a valuable target for disrupting their properties.
Authors
- Xiangqiong Wen (ORCID: https://orcid.org/0000-0002-7103-6014)
- Yuqin Di (ORCID: https://orcid.org/0000-0002-0576-1621)
- Qinghai Li (ORCID: https://orcid.org/0000-0003-0176-7708)
- Lvlan Ye (ORCID: https://orcid.org/0000-0002-9615-3356)
- Jiale Qin (ORCID: https://orcid.org/0000-0003-4769-4348)
- Youpeng Wang (ORCID: https://orcid.org/0000-0002-6453-4234)
- Xing Huang (ORCID: https://orcid.org/0000-0001-9982-8622)
- Xingfeng Qiu
- Ziyang Wang (ORCID: https://orcid.org/0000-0002-4259-5669)
- Xiang Zhang (ORCID: https://orcid.org/0000-0003-1003-9892)
- Qi Zhou (ORCID: https://orcid.org/0000-0001-5673-4263)
- Weiling He
Institutions
- Sun Yat-sen University (CN)
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-11
- DOI
- https://doi.org/10.1186/s12967-025-06103-3
- Citations
- 27
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 21.76
Funders
- National Natural Science Foundation of China