Coinfection with chikungunya and Zika results in mild disease and distinct inflammatory response

Chikungunya (CHIKV) and Zika (ZIKV) viruses, both mosquito-borne, often circulate simultaneously, raising concerns about the effects of coinfection. This study evaluated cytokines, chemokines, and growth factors in 12 patients with concurrent CHIKV and ZIKV infections confirmed by RT-qPCR. Clinical data and 45 immune mediators were analyzed. Coinfected and monoinfected patients exhibited similar symptoms, although ZIKV-infected individuals experienced fewer instances of fever. No patients had persistent symptoms or required hospitalization. Chemokines CCL5, CXCL1, and CXCL10 were elevated across all groups. CHIKV-infected patients showed higher levels of CCL2, CCL4, EGF, CXCL12, and IFN-α compared to controls, while IL-1RA, IL-8, and IFN-γ were elevated in both CHIKV and coinfected groups. SCF was elevated only in the ZIKV group. Overall, CHIKV and ZIKV coinfection presented mild clinical symptoms similar to monoinfections and demonstrated a moderate inflammatory response.

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Publication Details

Journal
npj Viruses
Published
2025-02-11
DOI
https://doi.org/10.1038/s44298-025-00098-w
Citations
2
Primary Topic
Mosquito-borne diseases and control
Type
article
Field-Weighted Citation Impact
3.76

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article

Coinfection with chikungunya and Zika results in mild disease and distinct inflammatory response

Amélia Ribeiro de Jesus, Jaira Vanessa de Carvalho, Priscila Lima dos Santos, Alejandra Debbo et al.
2 citations
npj Viruses
Mosquito-borne diseases and control
3.76
article

Coinfection with chikungunya and Zika results in mild disease and distinct inflammatory response

Amélia Ribeiro de Jesus, Jaira Vanessa de Carvalho, Priscila Lima dos Santos, Alejandra Debbo, Lucas Sousa Magalhães, Ângela Maria da Silva, Roque Pacheco de Almeida, Camilla Natália Oliveira Santos, Mauro Martins Teixeira, Suresh Mahalingam, Juliana Cardoso Alves, Regina Adalva de Lucena Couto Ócea
article en
2 citations

Abstract

Chikungunya (CHIKV) and Zika (ZIKV) viruses, both mosquito-borne, often circulate simultaneously, raising concerns about the effects of coinfection. This study evaluated cytokines, chemokines, and growth factors in 12 patients with concurrent CHIKV and ZIKV infections confirmed by RT-qPCR. Clinical data and 45 immune mediators were analyzed. Coinfected and monoinfected patients exhibited similar symptoms, although ZIKV-infected individuals experienced fewer instances of fever. No patients had persistent symptoms or required hospitalization. Chemokines CCL5, CXCL1, and CXCL10 were elevated across all groups. CHIKV-infected patients showed higher levels of CCL2, CCL4, EGF, CXCL12, and IFN-α compared to controls, while IL-1RA, IL-8, and IFN-γ were elevated in both CHIKV and coinfected groups. SCF was elevated only in the ZIKV group. Overall, CHIKV and ZIKV coinfection presented mild clinical symptoms similar to monoinfections and demonstrated a moderate inflammatory response.

npj VirusesVol. 3(1)
Universidade Federal de Minas Gerais (BR), Griffith University (AU), Universidade Federal de Sergipe (BR), Universidade Federal de Alagoas (BR)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Financiadora de Estudos e Projetos
Good health and well-being
Openalex Percentile: Top 9%
Mosquito-borne diseases and control
3.76
DOIOpen Access PDFOpenAlex
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