Arachidonic acid is involved in high-salt diet-induced coronary remodeling through stimulation of the IRE1α/XBP1s/RUNX2/OPN signaling cascade
ERS and AA were found to be stimulated in CASMCs following an HS diet. AA triggers an ERS response through COX-2 catalysis, and the downstream inositol requiring enzyme 1 - X-box binding protein-1 - osteopontin pathway may contribute to the AA-induced phenotypic transformation of CASMCs, resulting in dysfunctional coronary tension. This study may provide potential therapeutic targets for cardiovascular diseases associated with excessive AA-derived ERS.
Authors
- Bing Shen (ORCID: https://orcid.org/0000-0001-7263-4748)
- Jian‐Lin Wu (ORCID: https://orcid.org/0000-0002-3875-185X)
- Huimin Wang (ORCID: https://orcid.org/0000-0002-4692-4917)
- Zhuoran Jia
- Fang Liu (ORCID: https://orcid.org/0000-0001-8753-3878)
- Ren Zhao
- Peiyang Zheng
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-02-11
- DOI
- https://doi.org/10.1186/s12944-025-02465-1
- Citations
- 4
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- National Natural Science Foundation of China
- Anhui Medical University