The Association Between Promoter Tandem Repeat Polymorphism (pVNTR) and CYP2C9 Gene Expression in Human Liver Samples
Our results showed that pVNTR-S was associated with lower CYP2C9 expression (34% reduction, <i>p</i>-value = 0.032) in human liver samples (<i>n</i> = 247), while the known CYP2C9 biomarkers (CYP2C9*2, *3, *8, or rs12777823) were not. These results suggest that pVNTR-S reduces CYP2C9 expression independently of known biomarkers. Therefore, pVNTR-S may explain additional variability in CYP2C9 expression when present alone or in conjunction with other CYP2C9 alleles.
Authors
- Joseph M. Collins (ORCID: https://orcid.org/0000-0002-5487-4294)
- Daqing Wang (ORCID: https://orcid.org/0000-0002-7134-3065)
- Yan Gong (ORCID: https://orcid.org/0000-0002-8218-1620)
- A. de Montalvo (ORCID: https://orcid.org/0000-0003-4314-1295)
Institutions
- University of Florida (US)
Publication Details
- Journal
- Genes
- Published
- 2025-02-11
- DOI
- https://doi.org/10.3390/genes16020213
- Citations
- 3
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.67