Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin
In conclusion, our findings demonstrate that DIC sensitized HCC cells to IKE-induced ferroptosis in HCC. Moreover, the identification of potential drugs that enhance the susceptibility of HCC cells to ferroptosis could provide novel therapeutic strategies for the treatment of HCC.
Authors
- Jiao Wu (ORCID: https://orcid.org/0000-0002-9718-5499)
- Yaxin Ding
- Jialu Hou (ORCID: https://orcid.org/0000-0003-4737-7721)
- Zhi‐Nan Chen (ORCID: https://orcid.org/0000-0001-5512-4623)
- Yifei Qin (ORCID: https://orcid.org/0000-0003-0028-208X)
- Xiaohang Xie
- Tixin Han
- Ruibin Yang (ORCID: https://orcid.org/0000-0001-7873-0597)
- Fei Huo (ORCID: https://orcid.org/0000-0002-3402-2190)
- Yinuo Zhang (ORCID: https://orcid.org/0000-0001-8956-7334)
- Shijie Wang (ORCID: https://orcid.org/0000-0002-4760-0471)
- Lin Peng (ORCID: https://orcid.org/0009-0002-2724-8711)
- Jiali Yang (ORCID: https://orcid.org/0009-0008-3911-5549)
- Gang Zhou (ORCID: https://orcid.org/0000-0002-4798-5789)
- Ziwei Yang (ORCID: https://orcid.org/0009-0001-9058-8682)
- Zhuan Feng
Institutions
- Jinan University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1531874
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China
- Education Department of Shaanxi Province