<i>Porphyromonas gingivalis</i> and Its Outer Membrane Vesicles Induce Neuroinflammation in Mice Through Distinct Mechanisms
Pg is associated with a significant immune response and systemic inflammation, which in turn exacerbates neuroinflammation via activating NLRP3 inflammasome. However, Pg OMVs might elude the systemic immune response and disrupt tight junctions, thereby entering the brain and directly triggering neuroinflammation.
Authors
- Deqin Yang (ORCID: https://orcid.org/0000-0002-2579-8384)
- Guiqiong He
- Yu Qiu (ORCID: https://orcid.org/0000-0002-1236-1941)
- Yueyang Zhao (ORCID: https://orcid.org/0009-0006-5807-707X)
Institutions
- Capital Medical University (CN)
- Fudan University (CN)
- Beijing Tian Tan Hospital (CN)
- Shanghai Stomatological Hospital (CN)
- Stomatological Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/iid3.70135
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.05