Palladium‐Catalyzed Decarboxylative Coupling of Alkynoic Acids with 2‐Alkynylanilines in Ionic Liquid
Abstract An efficient and reliable NHC‐palladium‐catalyzed cascade decarboxylative coupling of alkynoic acids with 2‐alkynylanilines for the rapid and straightforward assembly of synthetically valuable 3‐alkynylindole derivatives in eco‐friendly medium is described. Control experiments revealed that NHC−Pd catalysts and base were all essential for this catalytic system. More importantly, this approach features mild reaction conditions, excellent functional group compatibility, and reasonable to excellent yields.
Authors
- Ruimin Zhong
- Ting Zhao (ORCID: https://orcid.org/0000-0002-0987-1043)
- Huanfeng Jiang (ORCID: https://orcid.org/0000-0002-4355-0294)
- Jianxiao Li (ORCID: https://orcid.org/0000-0002-5246-5729)
- Xun Xiong
- Wenfang Xiong (ORCID: https://orcid.org/0000-0001-6980-1648)
Institutions
- Guangdong Medical College (CN)
- Shaoguan University (CN)
- Key Laboratory of Guangdong Province (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-02-11
- DOI
- https://doi.org/10.1002/ajoc.202400767
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Department of Education of Guangdong Province
- National Key Research and Development Program of China
- Basic and Applied Basic Research Foundation of Guangdong Province