Multi-omics analysis reveals the impact of YAP/TEAD4-mediated EIF5A1 expression on mitochondrial apoptosis and bladder cancer progression
Our research demonstrates that EIF5A1 is upregulated in BLCA and associated with poor prognosis. We identified TEAD4 as a potential transcriptional regulator of EIF5A1 and showed that EIF5A1 expression is associated with changes in JAK2/STAT3 signaling and mitochondrial apoptosis in BLCA.
Authors
- Shanhui Liu (ORCID: https://orcid.org/0000-0001-9254-5339)
- Shun Wan
- Siyu Chen (ORCID: https://orcid.org/0000-0002-3809-1062)
- Li Wang (ORCID: https://orcid.org/0000-0003-0510-7985)
- Chenyang Wang (ORCID: https://orcid.org/0000-0002-8368-7754)
- Kunpeng Li (ORCID: https://orcid.org/0000-0003-1807-4545)
- Yang Li (ORCID: https://orcid.org/0000-0002-0752-6166)
Institutions
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-02-11
- DOI
- https://doi.org/10.1186/s12885-025-13522-4
- Citations
- 3
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 3.45