Synthesis and Evaluation of Colchicine C-Cyclic AmineDerivatives as Potent Anti-Biofilms Agents AgainstMethicillin-Resistant Staphylococcus aureus
The designed colchicine C-ring modified amine derivatives showed potential in inhibiting MRSA biofilms, and their antibacterial or synergistic antibacterial properties are related to the regulation of biofilm-related genes <i>icaA</i> and <i>agrA</i>, demonstrating inhibitory activity against MRSA.
Authors
- Chengli Sun (ORCID: https://orcid.org/0000-0002-2763-1043)
- Yuan Fang (ORCID: https://orcid.org/0000-0002-6338-6647)
- Zhengbin Tang (ORCID: https://orcid.org/0000-0002-6417-3723)
- Yuxin Yang (ORCID: https://orcid.org/0000-0002-1742-2328)
- Xin Liu (ORCID: https://orcid.org/0000-0002-6634-4012)
- Dachen Wang (ORCID: https://orcid.org/0000-0003-3294-0075)
- Xiaoping Zhou (ORCID: https://orcid.org/0000-0003-2831-635X)
- Zhanyi Sun (ORCID: https://orcid.org/0009-0007-4319-6030)
- Di Qu (ORCID: https://orcid.org/0000-0002-2701-0108)
Institutions
- Jilin University (CN)
Publication Details
- Journal
- Antibiotics
- Published
- 2025-02-10
- DOI
- https://doi.org/10.3390/antibiotics14020173
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China