Acute Transient Aminotransferase Elevation is Common With Intrathecal Methotrexate, but Liver Injury is Infrequent
Acute transient aminotransferase elevation is common after IT-MTX, especially in paediatric patients. Only a fraction of patients developed DILI, which was self-limited with no sensitisation or liver failure.
Authors
- Yaron Rotman (ORCID: https://orcid.org/0000-0002-7549-8216)
- Nirali N. Shah (ORCID: https://orcid.org/0000-0002-8474-9080)
- Mark Roschewski (ORCID: https://orcid.org/0000-0003-0278-2635)
- Julian Hercun (ORCID: https://orcid.org/0000-0001-7608-0914)
- Harish Gopalakrishna (ORCID: https://orcid.org/0000-0003-3175-4983)
Institutions
- National Institutes of Health (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- National Cancer Institute (US)
- Centre Hospitalier de l’Université de Montréal (CA)
- Center for Cancer Research (US)
Publication Details
- Journal
- Liver International
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1111/liv.70022
- Citations
- 2
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases