Maternal OM‐85 administration alleviates offspring allergic airway inflammation by downregulating IL‐33/ILC2 axis
Maternal OM-85 administration restrains ILC2-driven allergic airway inflammation in adult offspring by increasing offspring intestinal SCFAs to modulate ILC2 development at an early stage, demonstrating that the transgenerational effects of maternal OM-85 exposure on offspring innate immunity.
Authors
- Lei Chen (ORCID: https://orcid.org/0000-0002-9488-1173)
- Donghai Ma (ORCID: https://orcid.org/0000-0002-8769-0424)
- Baihe Wu (ORCID: https://orcid.org/0000-0002-7241-5139)
- Fengfei Sun
- Minmin Lin
- Zehu Chen
- Wei Zou (ORCID: https://orcid.org/0000-0001-5307-4685)
- Jing Liu (ORCID: https://orcid.org/0000-0003-4638-409X)
- Ying Chen (ORCID: https://orcid.org/0000-0002-6412-0568)
- Meizhu Chen (ORCID: https://orcid.org/0000-0002-0341-7480)
- Zibin Liang (ORCID: https://orcid.org/0000-0001-5866-5169)
- Xue‐Gang Li (ORCID: https://orcid.org/0000-0002-7400-7841)
- Honglei Shi (ORCID: https://orcid.org/0000-0002-0406-519X)
Institutions
- Sun Yat-sen University (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Pediatric Allergy and Immunology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/pai.70044
- Citations
- 5
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province