Lung tumor organoids migrate as cell clusters containing cancer stem cells under hypoxic condition
These findings highlight the value of lung tumor organoids as models for studying hypoxia's complex role in lung cancer. Hypoxia significantly modulates lung tumor organoids growth, stemness, and migratory behavior, providing critical insights into tumor progression and therapy resistance.
Authors
- Jun Zou (ORCID: https://orcid.org/0000-0003-2443-3516)
- Y. Li (ORCID: https://orcid.org/0000-0002-6171-0677)
- Yanhua Fang
- Ruoyu Wang (ORCID: https://orcid.org/0000-0002-0422-6408)
- Shanshan Liang (ORCID: https://orcid.org/0000-0002-1644-4496)
- Jiapeng Zuo
Institutions
- Affiliated Zhongshan Hospital of Dalian University (CN)
Publication Details
- Journal
- Biology of the Cell
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/boc.202400081
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China