The Pattern and Stages of Atrophy in Spinocerebellar Ataxia Type 2: Volumetrics from <scp>ENIGMA</scp>‐Ataxia
The magnitude and pattern of brain atrophy evolve over the course of SCA2, with widespread, nonuniform involvement across the brainstem, cerebellar tracts, and cerebellar cortex; and late involvement of the cerebral cortex and striatum. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Imis Dogan (ORCID: https://orcid.org/0000-0002-6632-197X)
- Sophia Göricke (ORCID: https://orcid.org/0000-0003-1552-4475)
- Anna Nigri (ORCID: https://orcid.org/0000-0002-1197-5458)
- Wolfgang Nachbauer (ORCID: https://orcid.org/0000-0001-8292-3690)
- Lorenzo Nanetti (ORCID: https://orcid.org/0000-0002-1952-4539)
- Sophia I. Thomopoulos (ORCID: https://orcid.org/0000-0002-0046-4070)
- Alexandra Dürr (ORCID: https://orcid.org/0000-0002-8921-7104)
- Francesco Saccà (ORCID: https://orcid.org/0000-0002-1323-6317)
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- Sandro Romanzetti (ORCID: https://orcid.org/0000-0001-8519-1309)
- Marina Grisoli (ORCID: https://orcid.org/0000-0002-7663-446X)
- Carlos R. Hernandez‐Castillo (ORCID: https://orcid.org/0000-0003-1208-5577)
- Jason W. Robertson (ORCID: https://orcid.org/0000-0003-0579-0403)
- Chiadi U. Onyike (ORCID: https://orcid.org/0000-0003-2255-4437)
- Fanny Mochel (ORCID: https://orcid.org/0000-0003-3970-3486)
- Caterina Mariotti (ORCID: https://orcid.org/0000-0003-2405-3564)
- Kathrin Reetz (ORCID: https://orcid.org/0000-0002-9730-9228)
- Isaac Adanyeguh (ORCID: https://orcid.org/0000-0003-1402-5877)
- Sergio Eiji Ono (ORCID: https://orcid.org/0000-0001-7997-0189)
- Benjamin Bender (ORCID: https://orcid.org/0000-0002-3205-4631)
- Hélio Afonso Ghizoni Teive (ORCID: https://orcid.org/0000-0003-2305-1073)
- Sylvia Boesch (ORCID: https://orcid.org/0000-0003-1657-7368)
- Ian H. Harding (ORCID: https://orcid.org/0000-0002-6843-9592)
- Dagmar Timmann (ORCID: https://orcid.org/0000-0003-1935-416X)
- Mario Mascalchi (ORCID: https://orcid.org/0000-0002-5537-2982)
- Jerry L. Prince (ORCID: https://orcid.org/0000-0002-6553-0876)
- Stefano Diciotti (ORCID: https://orcid.org/0000-0001-8778-7819)
- Shuo Han (ORCID: https://orcid.org/0000-0003-2033-9004)
- Sirio Cocozza (ORCID: https://orcid.org/0000-0002-0300-5160)
- Juan Fernández-Ruíz (ORCID: https://orcid.org/0000-0002-4038-0904)
- Léo Coutinho (ORCID: https://orcid.org/0000-0003-4921-2939)
- Andreas Deistung (ORCID: https://orcid.org/0000-0002-2427-1302)
- Chiara Marzi (ORCID: https://orcid.org/0000-0002-1791-3573)
- Arturo Brunetti (ORCID: https://orcid.org/0000-0001-7057-3494)
- Paul M. Thompson (ORCID: https://orcid.org/0000-0002-4720-8867)
- Sarah H. Ying
Institutions
- University of Southern California (US)
- Centre National de la Recherche Scientifique (FR)
- Dalhousie University (CA)
- Innsbruck Medical University (AT)
- Johns Hopkins University (US)
- Inserm (FR)
- Universität Innsbruck (AT)
- QIMR Berghofer Medical Research Institute (AU)
- Marconi University (IT)
- German Center for Neurodegenerative Diseases (DE)
- Sorbonne Université (FR)
- Centrus Diagnósticos por Imagem (BR)
- Laboratori Guglielmo Marconi (Italy) (IT)
- Essen University Hospital (DE)
- Pitié-Salpêtrière Hospital (FR)
- Jülich Aachen Research Alliance (DE)
- Hospital de Clínicas Universidade Federal do Paraná (BR)
- Hertie Institute for Clinical Brain Research (DE)
- University Hospital in Halle (DE)
- Institut du Cerveau (FR)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- University of Florence (IT)
- Universidade Federal do Paraná (BR)
- Monash University (AU)
- University of Duisburg-Essen (DE)
- University of Naples Federico II (IT)
- RWTH Aachen University (DE)
- Universidad Nacional Autónoma de México (MX)
- University of Bologna (IT)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1002/mds.30143
- Citations
- 1
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Science Foundation
- National Ataxia Foundation
- Johns Hopkins University
- Deutsche Forschungsgemeinschaft
- Canada Research Chairs
- Bundesministerium für Bildung und Forschung
- Consejo Nacional de Ciencia y Tecnología
- Ministero della Salute
- National Institutes of Health
- Natural Sciences and Engineering Research Council of Canada
- Medical Research Council
- National Health and Medical Research Council
- Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México
- National Institute of Neurological Disorders and Stroke
- National Center for Advancing Translational Sciences