Monte Carlo study of gold nanoparticle‐mediated radiosensitization effects using nanoscale cell model combined with fractal‐based DNA model

With a realistic fractal-based chromatin fiber arrangement of DNA within the nucleus, the currently developed TEM-based cellular geometry model enabled the unprecedented investigation of radiation-induced DNA damage in a single GNP-laden cell using track structure Geant4 MC simulations. The modeling approaches and findings from this study significantly enhance our ability and knowledge to conduct computational investigations of GNP-mediated radiosensitization, possibly leading to the development of a predictive biological outcome model with minimal empiricism.