N<sup>6</sup>‐Methyladenosine modification mediated by METTL3 promotes DNA‐PKcs expression to induce anlotinib resistance in osteosarcoma
DNA-PKcs knockdown heightens osteosarcoma sensitivity to anlotinib. DNA-PKcs modulates anlotinib-induced protective autophagy through interacts with Beclin-1 and regulates its ubiquitination. m<sup>6</sup>A modification of OLE_LINK82PRKDC mRNA induced by METTL3 contributes to anlotinib resistance in osteosarcoma. m<sup>6</sup>A methylation of PRKDC mRNA recognised by YTHDF1 amplifies the expression of DNA-PKcs.
Authors
- Zhaorui Lv (ORCID: https://orcid.org/0000-0001-5686-3452)
- Guohong Shen
- Ka Li (ORCID: https://orcid.org/0009-0006-9528-9864)
- Dan Zhang (ORCID: https://orcid.org/0000-0003-1728-9069)
- Tingting Meng (ORCID: https://orcid.org/0000-0002-1072-8666)
- Lihui Chen (ORCID: https://orcid.org/0000-0001-7452-1675)
- Yining Zhang (ORCID: https://orcid.org/0000-0001-5468-9702)
- Jianmin Li (ORCID: https://orcid.org/0009-0001-8966-4203)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Shandong University (CN)
- Jinan Central Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/ctm2.70228
- Citations
- 6
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.84