Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis
Chaperone-mediated autophagy (CMA) deficiency in hepatocytes promotes hepatic inflammation and fibrosis in mice with nonalcoholic steatohepatitis (NASH) by inducing cholesterol accumulation and endoplasmic reticulum (ER) stress. Upregulated FOXM1 impairs CMA by suppressing the transcription of lysosome-associated membrane protein 2A (LAMP2A), a rate-limiting component of CMA. ER stress increases FOXM1 expression and cholesterol accumulation. FOXM1/CMA/ER stress axis forms a vicious circle and promotes the development of NASH.
Authors
- Xinmin Zhou (ORCID: https://orcid.org/0000-0002-6443-7557)
- Gang Ma (ORCID: https://orcid.org/0000-0001-5270-8666)
- Keshuai Sun (ORCID: https://orcid.org/0009-0006-5395-3659)
- Siyuan Tian
- Guanya Guo (ORCID: https://orcid.org/0000-0001-5115-1632)
- Changcun Guo (ORCID: https://orcid.org/0000-0002-9016-9699)
- Yulong Shang (ORCID: https://orcid.org/0000-0002-8576-3175)
- Qingling Fan
- Yinan Hu (ORCID: https://orcid.org/0000-0002-9304-519X)
- Ying Han (ORCID: https://orcid.org/0000-0003-3046-9507)
- Xia Zhou (ORCID: https://orcid.org/0000-0002-7755-8876)
- Bo Li (ORCID: https://orcid.org/0000-0001-6572-5633)
- Miao Zhang (ORCID: https://orcid.org/0000-0002-4242-005X)
- Jingbo Wang (ORCID: https://orcid.org/0000-0002-4961-0921)
- Xiaohong Zheng (ORCID: https://orcid.org/0009-0005-8570-8802)
- Rui Su (ORCID: https://orcid.org/0000-0002-4807-6229)
- Erzhuo Xia
- Shuoyi Ma (ORCID: https://orcid.org/0000-0001-7306-2489)
- Fangfang Yang (ORCID: https://orcid.org/0000-0003-3521-6947)
Institutions
- 81th Hospital of PLA (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/ctm2.70202
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- National Natural Science Foundation of China