Association of Physicians of India Consensus Recommendations for Vonoprazan in Management of Acid Peptic Disorders
The suppression of gastric acid secretion has long been the cornerstone of treatment for acid peptic disorders (APDs). Proton pump inhibitors (PPIs) have played a central role in managing these conditions, but their effectiveness can be hindered by notable limitations such as refractoriness or treatment failure due to inadequate acid suppression in some gastroesophageal reflux disease (GERD) patients, nonadherence to prescribed regimens due to the complexity of dosing, variability of response, and nocturnal acid breakthrough, etc. Vonoprazan is a first-in-class potassium-competitive acid blocker (P-CAB), recently introduced in India and also approved in several countries such as Japan, South Korea, and the USA. Extensive clinical evidence suggests that vonoprazan offers more potent acid suppression than PPIs. This consensus from the Association of Physicians of India (API) has been developed with the objective of providing key recommendations for the appropriate clinical usage of vonoprazan across various subsets of APDs, thereby optimizing the existing therapeutic options and improving the care and management of APD patients.
Authors
- Dwaipayan Mukherjee (ORCID: https://orcid.org/0000-0002-3918-3188)
- Rakesh Bhadade
- Milind Nadkar
- Amit Qamra
- Samir M. Parikh (ORCID: https://orcid.org/0000-0002-1038-981X)
- Agam Vora (ORCID: https://orcid.org/0000-0002-9632-1807)
- Naik Arun
- Deepak Haldipur
- Samir Bhargava (ORCID: https://orcid.org/0000-0002-9694-4617)
- Surya Kant (ORCID: https://orcid.org/0000-0001-7520-5404)
- Nilima Soni (ORCID: https://orcid.org/0009-0002-7537-0068)
- Rajagopal Ramesh (ORCID: https://orcid.org/0000-0002-7658-5338)
- Shiran Shetty (ORCID: https://orcid.org/0000-0003-3727-0488)
- Umesh Jalihal (ORCID: https://orcid.org/0000-0002-5983-4750)
- Shailesh Pallewar
- Ashwin Kotamkar
- Dwijen Das
- Amit Saraf (ORCID: https://orcid.org/0009-0007-7952-9212)
- Rajesh Kumar (ORCID: https://orcid.org/0000-0002-7656-4465)
- Mangesh Tiwaskar
- V. G. Mohan Prasad
- Rajesh Upadhyay
Institutions
- Apollo Hospitals (IN)
- SMS Medical College (IN)
- King Edward Memorial Hospital and Seth G.S. Medical College (IN)
- Lilavati Hospital & Research Centre (IN)
- P. D. Hinduja Hospital and Medical Research Centre (IN)
- Government ENT Hospital (IN)
- Max Super Speciality Hospital (IN)
- King George's Medical University (IN)
- Topiwala National Medical College & BYL Nair Charitable Hospital (IN)
- Shilpa (India) (IN)
- Surya Hospitals (IN)
- KG Hospital (IN)
- Tezpur Medical College & Hospital (IN)
- VGM Gastro Centre (IN)
- Jupiter Medical Center (US)
- Orthopaedic Research Group (IN)
- Apollo Hospitals (IN)
- Glenmark Pharmaceuticals (India) (IN)
- Bombay Hospital (IN)
- Apollo Hospitals (IN)
- Kasturba Medical College, Manipal (IN)
- Bangalore Medical College and Research Institute (IN)
Publication Details
- Journal
- Journal of the Association of Physicians of India
- Published
- 2025-02-01
- DOI
- https://doi.org/10.59556/japi.73.0844
- Citations
- 3
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.43