Causal survival embeddings: Non-parametric counterfactual inference under right-censoring

Counterfactual inference at the distributional level presents new challenges with censored targets, especially in modern healthcare problems. To mitigate selection bias in this context, we exploit the intrinsic structure of reproducing kernel Hilbert spaces (RKHS) harnessing the notion of kernel mean embedding. This enables the development of a non-parametric estimator of counterfactual survival functions. We provide rigorous theoretical guarantees regarding consistency and convergence rates of our new estimator under general hypotheses related to smoothness of the underlying RKHS. We illustrate the practical viability of our methodology through extensive simulations and a relevant case study: The SPRINT trial. Our estimatort presents a distinct perspective compared to existing methods within the literature, which often rely on semi-parametric approaches and confront limitations in causal interpretations of model parameters.

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Publication Details

Journal
Statistical Methods in Medical Research
Published
2025-02-11
DOI
https://doi.org/10.1177/09622802241311455
Citations
1
Primary Topic
Advanced Causal Inference Techniques
Type
article
Field-Weighted Citation Impact
2.63

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article

Causal survival embeddings: Non-parametric counterfactual inference under right-censoring

Carlos García Meixide, Marcos Matabuena
1 citations
Statistical Methods in Medical Research
Advanced Causal Inference Techniques
2.63
article

Causal survival embeddings: Non-parametric counterfactual inference under right-censoring

Carlos García Meixide, Marcos Matabuena
article en
1 citations

Abstract

Counterfactual inference at the distributional level presents new challenges with censored targets, especially in modern healthcare problems. To mitigate selection bias in this context, we exploit the intrinsic structure of reproducing kernel Hilbert spaces (RKHS) harnessing the notion of kernel mean embedding. This enables the development of a non-parametric estimator of counterfactual survival functions. We provide rigorous theoretical guarantees regarding consistency and convergence rates of our new estimator under general hypotheses related to smoothness of the underlying RKHS. We illustrate the practical viability of our methodology through extensive simulations and a relevant case study: The SPRINT trial. Our estimatort presents a distinct perspective compared to existing methods within the literature, which often rely on semi-parametric approaches and confront limitations in causal interpretations of model parameters.

Statistical Methods in Medical ResearchVol. 34(3)
Harvard University Press (US), ETH Zurich (CH), Institute of Mathematical Sciences (ES), Universidad Autónoma de Madrid (ES)
National Heart, Lung, and Blood Institute
Reduced inequalities, Peace, Justice and strong institutions
Openalex Percentile: Top 15%
Advanced Causal Inference Techniques
2.63
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