Indications for the Use of Vitamin D in Everyday Life Clinical Practice in Individuals with Cerebral Palsy

There is currently an increasing demand for chronic inflammation to be recognized as a comorbidity in cerebral palsy (CP). A broad immunomodulatory and anti- inflammatory strategy in therapy management should be introduced into daily care. Vitamin D status is increasingly recognized as an important aspect, as the steroid hormone is attributed to a complex physiological function. In summary, by 2024 there will be sufficient pathoimmunological evidence that children with CP will benefit significantly from daily high- dose vitamin D supplementation throughout their lives. The reduction of chronic inflammation in the CNS, positive effects on the skeletal and muscular system, prevention and therapeutic support of infections are the target for the active form of vitamin D, 1,25-dihydroxy-vitamin D3 (calcitriol). In particular, quality of life is increased by improving reduced muscle performance and reducing the potential risk of falls. Children with PC are prone to hypovitaminosis D and about half of the children had a vitamin D deficiency. If the Endocrine Society empirically recommends vitamin D supplementation for healthy children and adolescents aged 1 to 18 years to prevent disease , this treatment option should be used because of cytokine dysregulation in CP with poorer neurological development . Proactive therapy with vitamin D supplementation is equally important in women who want to have children, primarily to reduce the risk of CP.