Huayu Tongbi formula attenuates rheumatoid arthritis by inhibiting the HIF1A/VEGFA/ANGPT axis and suppressing angiogenesis
HT has a promising effect on alleviating RA angiogenesis, at least in part through HIF1A-VEGFA-ANGPT axis inhibition, which reduces the cross-talk between RA-FLS and HUVECs. Our results suggest that HT is a drug candidate for the treatment of RA angiogenesis.
Authors
- Qingchun Huang
- Runyue Huang (ORCID: https://orcid.org/0000-0003-1532-1766)
- Jiaqi Wu (ORCID: https://orcid.org/0000-0002-9367-675X)
- Xiang Guo (ORCID: https://orcid.org/0009-0005-9940-9037)
- Maojie Wang (ORCID: https://orcid.org/0000-0003-1417-416X)
- Haifang Du (ORCID: https://orcid.org/0000-0002-5721-1779)
- Zifeng Chen
- Simin Wu (ORCID: https://orcid.org/0000-0002-1547-6947)
- Huiming Liang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-02-11
- DOI
- https://doi.org/10.1016/j.phymed.2025.156479
- Citations
- 15
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 35.72
Funders
- National Natural Science Foundation of China
- Science and Technology Planning Project of Guangdong Province