Corticosterone‐Induced Myocardial Dysfunctions and the Cardioprotective Role of Tauroursodeoxycholic Acid: An Experimental Study in Mice
Overall, our results suggest that corticosterone induces depression-like behaviours, cardiac dysfunction, elevated serum NE levels, reduced ATP and a decreased Bcl-2/Bax ratio, disrupting myocardial contraction and mitochondrial function. TUDCA effectively reversed these effects and modulated genes linked to muscle contraction and ion transport, highlighting its potential in mitigating corticosterone-induced behavioural and cardiac impairments.
Authors
- Xiaoying Chen (ORCID: https://orcid.org/0009-0002-3182-0856)
- Hailian Shi (ORCID: https://orcid.org/0000-0002-7870-0758)
- Xiaojun Wu (ORCID: https://orcid.org/0000-0001-6554-5341)
- Houyuan Zhou
- Zikang Li (ORCID: https://orcid.org/0000-0001-5177-3853)
- Fei Huang
- Hui Wu (ORCID: https://orcid.org/0000-0002-1465-5847)
- Yanlin Tao (ORCID: https://orcid.org/0000-0001-7315-6127)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Clinical and Experimental Pharmacology and Physiology
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1111/1440-1681.70027
- Citations
- 2
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Natural Science Foundation of Shanghai