SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity
Our investigation of the SOCS1 pathway in AML and T-cell interactions provides insights into potential mechanisms of resistance of AML to allogeneic hematopoietic stem cell transplantation and demonstrates the potential of targeting SOCS1 and its downstream mediators to enhance antileukemic T-cell activity. See related commentary by Fry, p. 157.
Authors
- Neil MacLean
- Jong Bok Lee (ORCID: https://orcid.org/0000-0002-4744-6021)
- Mark D. Minden (ORCID: https://orcid.org/0000-0002-9089-8816)
- Sergio Rutella (ORCID: https://orcid.org/0000-0003-1970-7375)
- Yoosu Na
- Jayakumar Vadakekolathu (ORCID: https://orcid.org/0000-0002-2671-4285)
- Aaron David Schimmer (ORCID: https://orcid.org/0000-0003-4023-3899)
- Enoch Tin (ORCID: https://orcid.org/0000-0001-7838-0400)
- Yongran Yan (ORCID: https://orcid.org/0009-0005-7337-4331)
- Zhang Li (ORCID: https://orcid.org/0000-0003-4649-0757)
- Ismat Khatri
Institutions
- University Health Network (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Toronto General Hospital (CA)
- Princess Margaret Cancer Centre (CA)
- Nottingham Trent University (GB)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1158/2643-3230.bcd-24-0140
- Citations
- 5
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 5.23