Cerebrospinal fluid and serum cytokine profiles in severe viral encephalitis with implications for refractory status epilepticus: a retrospective observational study
Patients with SVE exhibit intrathecal cytokine storms, primarily characterized by elevated levels of IL-6 and IL-8, which influence prognosis. The strong and persistent hyperinflammation underscored by CSF IL-6 and IL-8 is associated with the occurrence and development of RSE; thus, CSF IL-8 and age are independent risk factors for SVE with RSE, indicating potential anti-inflammatory intervention targets.
Authors
- Dandan Song (ORCID: https://orcid.org/0009-0000-5333-2955)
- Ruirui Dong (ORCID: https://orcid.org/0000-0002-0464-4781)
- Fan Yang (ORCID: https://orcid.org/0000-0002-7883-9573)
- Junfang Teng (ORCID: https://orcid.org/0000-0001-7916-6131)
- Junshuang Guo
- Jinjin Qin
- Qiuling Zang
- Zhiping Ren
- Yating Wang (ORCID: https://orcid.org/0000-0002-2030-6176)
- Lijun Wen (ORCID: https://orcid.org/0000-0002-2508-6168)
- Peipei Huang (ORCID: https://orcid.org/0009-0005-2362-7054)
- Wang Miao (ORCID: https://orcid.org/0000-0003-2289-2962)
- Ruike Zhang (ORCID: https://orcid.org/0009-0008-8686-3793)
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1528763
- Citations
- 1
- Primary Topic
- Infectious Encephalopathies and Encephalitis
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Zhengzhou University