Gingival fibroblast suppress the osteogenesis process mediated by bone substitute materials via WNT/β-catenin signaling pathway in vitro and in vivo
Our study demonstrates that gingival fibroblasts can suppress the osteogenic potential of BSMs by inhibiting the autocrine WNT expression and the activation of the WNT/β-catenin signaling pathway in MMSCs. These findings highlight the importance of considering the cellular microenvironment in tissue engineering and regenerative medicine and suggest potential targets for modulating MMSCs behavior to enhance bone regeneration.
Authors
- Jiahui Lin
- Guanqi Liu (ORCID: https://orcid.org/0000-0002-9109-2179)
- Runheng Liu (ORCID: https://orcid.org/0000-0003-1517-4137)
- Xiaoyan Chen (ORCID: https://orcid.org/0009-0004-8800-4459)
Institutions
- Sun Yat-sen University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-02-10
- DOI
- https://doi.org/10.3389/fbioe.2025.1521134
- Citations
- 2
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.67
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province