Pan-caspase inhibitor protects against noise-induced hearing loss in a rodent model
Our findings indicate that a single intraperitoneal injection of Z-VAD-FMK can partially mitigate cochlear dysfunction induced by acoustic overexposure in a rodent model, highlighting its potential as a therapeutic intervention for NIHL.
Authors
- Mario O. Salazar (ORCID: https://orcid.org/0000-0002-0006-7614)
- Manuel Yepes (ORCID: https://orcid.org/0000-0002-5224-9663)
- Suhrud M. Rajguru (ORCID: https://orcid.org/0000-0001-5953-8516)
- Federica Maddalena Raciti (ORCID: https://orcid.org/0000-0002-4720-9448)
- Kayla Minesinger
Institutions
- University of Miami (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-02-10
- DOI
- https://doi.org/10.3389/fnins.2025.1497773
- Citations
- 1
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 1.46
Funders
- U.S. Department of Defense
- U.S. Department of Veterans Affairs
- National Institutes of Health
- U.S. Army Medical Research Acquisition Activity