Case report: an unusual long-term evolution of a diffuse midline glioma, H3K27 altered
Despite a more precise, molecularly driven classification of pediatric HGG (high-grade glioma) in the 5th edition of the WHO classification of CNS tumors, many genetic factors influencing the biological tumor development as well as the precise molecular evolution of tumors remain unclear. Given the highly aggressive clinical course of these tumors, with a median overall survival around 16 to 18 months, our report of a (presumable) precursor lesion years before clinical manifestation point towards a complex, multi-stage evolution of this tumor entity. Better understanding this molecular cascade might help to identify novel targets for individualized therapies.
Authors
- Marie‐Christin Metz (ORCID: https://orcid.org/0000-0002-1459-5741)
- Claire Delbridge (ORCID: https://orcid.org/0000-0003-4339-6917)
- Benedikt Wiestler (ORCID: https://orcid.org/0000-0002-2963-7772)
- Arthur Wagner (ORCID: https://orcid.org/0000-0001-9947-2240)
- Michael Griessmair (ORCID: https://orcid.org/0009-0007-3518-0792)
- Eva Mayr (ORCID: https://orcid.org/0000-0001-8402-5990)
- Claus Zimmer (ORCID: https://orcid.org/0000-0002-4805-9103)
- Julian Canisius (ORCID: https://orcid.org/0009-0002-4490-8021)
Institutions
- University of Bern (CH)
- University Hospital of Bern (CH)
- TUM Klinikum (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-02-10
- DOI
- https://doi.org/10.3389/fonc.2025.1480247
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63