A prognostic signature of Glutathione metabolism-associated long non-coding RNAs for lung adenocarcinoma with immune microenvironment insights
This study identified GSH metabolism-related lncRNAs as key prognostic factors in LUAD and developed a model for risk stratification. High-risk patients showed increased tumor mutation burden (TMB) and stemness, emphasizing the potential of personalized immunotherapy to improve survival outcomes.
Authors
- Jun Wu (ORCID: https://orcid.org/0000-0002-1891-368X)
- Xiaolin Wang (ORCID: https://orcid.org/0000-0001-5029-982X)
- Jiaqi Hou (ORCID: https://orcid.org/0000-0002-5803-7303)
- Shuyu Tian
- Qingwen Liu (ORCID: https://orcid.org/0000-0002-5239-0608)
- Yusheng Shu (ORCID: https://orcid.org/0000-0002-8423-0422)
- Junxi Hu
Institutions
- Dalian Medical University (CN)
- Northern Jiangsu People's Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1477437
- Citations
- 4
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 3.75