The mcpC mutant of Salmonella enteritidis exhibits attenuation and confers both immunogenicity and protective efficacy in mice
This study demonstrates that deletion of the <i>mcpC</i> gene attenuates the virulence of <i>SE</i>. The Δ<i>mcpC</i> offers strong immune protection in mice, providing a solid foundation for the development of genetically engineered attenuated live vaccines against <i>SE</i>.
Authors
- Qingfeng Zheng
- Yanying Zhang (ORCID: https://orcid.org/0000-0002-2097-9207)
- Yun Li (ORCID: https://orcid.org/0000-0001-5084-6272)
- Xuqiang Zhang
- Ning Li
- Chen Li (ORCID: https://orcid.org/0000-0002-8784-8148)
- Lu Zhang (ORCID: https://orcid.org/0000-0002-9130-8304)
- Yang Li (ORCID: https://orcid.org/0009-0006-8280-5284)
- Qiumei Shi (ORCID: https://orcid.org/0009-0004-3906-0972)
- Tonglei Wu
Institutions
- Tangshan College (CN)
- Hebei Normal University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-02-10
- DOI
- https://doi.org/10.3389/fmicb.2025.1548920
- Citations
- 1
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Beijing University of Agriculture