Association of per- and polyfluoroalkyl substances with gout risk: a cross-sectional analysis of NHANES 2007–2018 data emphasizing mixture effects
This study provides evidence for a potential link between PFAS exposure and gout risk, particularly when considering mixtures. While associations with individual PFASs are largely explained by demographic and lifestyle factors, the persistent association of mixtures with gout risk highlights the importance of considering combined exposures in environmental health research. Uric acid level plays a crucial intermediary effect.
Authors
- Shiqing Huang
- Bingsong Zhang (ORCID: https://orcid.org/0000-0002-4904-6961)
- Xin Peng (ORCID: https://orcid.org/0000-0001-9277-8415)
- Ruihao Huang
- Chongxiang Xiong (ORCID: https://orcid.org/0000-0003-3988-5881)
- Lihua He (ORCID: https://orcid.org/0000-0002-4166-751X)
- Yan Han (ORCID: https://orcid.org/0000-0002-7654-0906)
- Hansheng Feng (ORCID: https://orcid.org/0000-0002-5178-252X)
- Siran Li (ORCID: https://orcid.org/0000-0002-3137-7965)
- Renhuizi Wei (ORCID: https://orcid.org/0009-0004-9904-4384)
Institutions
- Guangdong Medical College (CN)
- Dongguan People’s Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Public Health
- Published
- 2025-02-10
- DOI
- https://doi.org/10.3389/fpubh.2025.1484663
- Citations
- 1
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- National Natural Science Foundation of China
- Natural Science Foundation for Young Scientists of Shanxi Province
- Young Scientists Fund
- Basic and Applied Basic Research Foundation of Guangdong Province