Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery
Aim of study is to analyze Bromelain' effects on the most common early complications after BCS (oedema and seroma). From January 2021 to December 2023 a double-blind randomized placebo-controlled trial was performed on 114 candidates for BCS at our Academic Unit. Group A received a supplement of Casperome™-Boswellia Phytosome<sup>®</sup> + Bromelain (CBB) in combination with alpha-lipoic acid + superoxide dismutase + B and D vitamins + centella asiatica. Group B received a supplement of CBB + placebo. Group C received placebo. The therapies were administrated for 30 days. On GEE logistic regression, drugs combination in A seems to be associated with statistical fewer oedema compared with C (P = 0.018 at 1 day and P = 0.002 after 1 month). Comparing B to C, B gained a significative value after 1 month (P = 0.007). On GEE logistic regression, the drugs combination in A has been associated with statistical fewer seroma compared with C (P = 0.009 at 15thpostoperative day and P < 0.001 after 1 month). B vs C reaches significant values 15 day and 1 month after surgery (P = 0.002 and P < 0.001, respectively). The current study is the first analyzing the employment of CBB association with/without neurotrophic agent on prevention of early complications after BCS.
Authors
- Claudia Angelini (ORCID: https://orcid.org/0000-0001-8350-8464)
- Silvia Gentile
- L. Clemente (ORCID: https://orcid.org/0009-0006-3736-6905)
- L. Lapadula
- Giuseppe Giudice (ORCID: https://orcid.org/0000-0003-3883-8901)
- Francesco Paolo Prete (ORCID: https://orcid.org/0000-0003-0426-8752)
- M. Lambo
- Antonio Carrieri (ORCID: https://orcid.org/0000-0002-7725-6667)
- Giuseppe Massimiliano De Luca (ORCID: https://orcid.org/0000-0002-9990-5795)
- Francesca Iuele (ORCID: https://orcid.org/0009-0003-5567-6171)
- Tiziana Grassi (ORCID: https://orcid.org/0000-0003-1200-2778)
- Alessandro Pasculli (ORCID: https://orcid.org/0000-0003-2276-2383)
- Alessandro Nitti (ORCID: https://orcid.org/0000-0002-4923-6597)
- W. Lavermicocca
- Filomena Puntillo (ORCID: https://orcid.org/0000-0001-7274-6467)
- Valentina Ronghi
- Mario Testini (ORCID: https://orcid.org/0000-0002-9297-4894)
- Fernando Palma (ORCID: https://orcid.org/0000-0002-0261-1150)
- Pasquale Tedeschi (ORCID: https://orcid.org/0000-0002-1353-2052)
- Gabriella Serio (ORCID: https://orcid.org/0000-0001-9021-4560)
- Mariateresa Giglio (ORCID: https://orcid.org/0000-0002-4901-0045)
- Marco Moschetta (ORCID: https://orcid.org/0000-0003-1771-8337)
- M. Telegrafo
- Nicoletta Resta (ORCID: https://orcid.org/0000-0001-8640-5532)
- Angela Gurrado (ORCID: https://orcid.org/0000-0002-2009-5831)
- Marco Favetta (ORCID: https://orcid.org/0000-0002-9544-3407)
- Valentina Lorusso
- Mauro G. Mastropasqua (ORCID: https://orcid.org/0000-0002-8306-0839)
- Michele Maruccia (ORCID: https://orcid.org/0000-0002-2122-2732)
- Lucia Ilaria Sgaramella (ORCID: https://orcid.org/0000-0002-6087-4119)
- Luigia Stefania Stucci (ORCID: https://orcid.org/0000-0003-2063-1435)
- Michele Piombino (ORCID: https://orcid.org/0009-0004-6020-7852)
- Concetta Caporusso (ORCID: https://orcid.org/0009-0004-0502-5706)
- E. Lacalendola
- Aaron L. Magno (ORCID: https://orcid.org/0000-0001-6099-819X)
- Rossella Elia (ORCID: https://orcid.org/0000-0002-6094-5159)
- Patrizia Dicillo
- Giuseppe Rubini (ORCID: https://orcid.org/0000-0003-1972-3308)
- Luigi Macchia (ORCID: https://orcid.org/0000-0002-5896-086X)
- Corinna Altini (ORCID: https://orcid.org/0000-0002-8949-2405)
- A Pisani
- E Poli
- Antonio Giorgio
- M. Amendolagine
- C. Deleo
- V. Deruvo
- G. L. Digiulio
- S. Mastrorillo
- F. Solfrizzo
Institutions
- Istituto Tumori Bari (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1038/s41598-025-86651-2
- Citations
- 1
- Primary Topic
- Biochemical Acid Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.11