Exploring Origin-Dependent Susceptibility of Smooth Muscle Cells to Aortic Diseases Through Intersectional Genetics
Our approach to genetically targeting SMC subtypes provides a novel platform for exploring origin-dependent or location-specific aortic vascular diseases. This genetic system enables comprehensive analysis of contributions from different cell lineages to SMC behavior and pathology, thereby paving the way for targeted research and therapeutic interventions in the future.
Authors
- Wenjuan Pu (ORCID: https://orcid.org/0000-0001-5155-5178)
- Ximeng Han
- Huan Zhao (ORCID: https://orcid.org/0000-0001-6319-949X)
- Xiuzhen Huang (ORCID: https://orcid.org/0000-0002-4087-8964)
- Yufei Zhao (ORCID: https://orcid.org/0000-0002-4918-2429)
- Ruling Shen (ORCID: https://orcid.org/0000-0002-7529-810X)
- Zixin Liu (ORCID: https://orcid.org/0000-0002-1085-8911)
- Lixin Wang (ORCID: https://orcid.org/0000-0002-1379-3906)
- Kathy O. Lui (ORCID: https://orcid.org/0000-0002-1616-3643)
- Linghong Shen (ORCID: https://orcid.org/0000-0002-4387-4109)
- Ben He (ORCID: https://orcid.org/0009-0006-8069-8198)
- Xin Ma (ORCID: https://orcid.org/0000-0001-8525-068X)
- Enci Wang
- Huan Zhu (ORCID: https://orcid.org/0000-0002-0731-2547)
- Yán Li (ORCID: https://orcid.org/0000-0003-4537-7672)
- Qing‐Dong Wang (ORCID: https://orcid.org/0000-0001-9570-4411)
- Kuo Liu (ORCID: https://orcid.org/0000-0003-0757-7833)
- Yi Li (ORCID: https://orcid.org/0000-0001-6166-8109)
- Bin Zhou (ORCID: https://orcid.org/0000-0001-5278-5522)
- Mingjun Zhang (ORCID: https://orcid.org/0000-0002-7977-9509)
- Xiao Yang (ORCID: https://orcid.org/0000-0002-0298-9831)
Institutions
- Jiangnan University (CN)
- Chinese University of Hong Kong (HK)
- Fudan University (CN)
- Shanghai Chest Hospital (CN)
- ShanghaiTech University (CN)
- Westlake University (CN)
- China Animal Disease Control Center (CN)
- Shanghai Institute of Materia Medica (CN)
- Prince of Wales Hospital (CN)
- Center for Excellence in Molecular Cell Science (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
- AstraZeneca (Finland) (FI)
- Drug Discovery Laboratory (Norway) (NO)
- Beijing Proteome Research Center (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Circulation
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1161/circulationaha.124.070782
- Citations
- 7
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 5.64