Overlooked Carbamazepine Toxicity: A Diagnostic Pitfall in an Elderly Patient With Dizziness

Dizziness is a common chief complaint that often poses a diagnostic challenge. A 79-year-old man was initially misdiagnosed with peripheral vertigo based on normal neuroimaging but later developed altered consciousness and involuntary limb movements, ultimately revealing carbamazepine (CBZ) toxicity. This case highlights a critical diagnostic pitfall: prematurely attributing dizziness to peripheral vertigo without considering drug-induced syndromes. Although the potential role of concomitant amiodarone use remains uncertain, this case also underscores the importance of cautious CBZ dose escalation, serum level monitoring, and a thorough medication review. Recognizing CBZ toxicity as a mimicker of central vertigo is crucial for ensuring timely and accurate diagnosis, especially in elderly patients.

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Publication Details

Journal
Cureus
Published
2025-02-10
DOI
https://doi.org/10.7759/cureus.78802
Primary Topic
Epilepsy research and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Overlooked Carbamazepine Toxicity: A Diagnostic Pitfall in an Elderly Patient With Dizziness

Katsuhiro Kobayashi, Takayuki Ando, Ayano Hamai
Cureus
Epilepsy research and treatment
article

Overlooked Carbamazepine Toxicity: A Diagnostic Pitfall in an Elderly Patient With Dizziness

Katsuhiro Kobayashi, Takayuki Ando, Ayano Hamai
article en

Abstract

Dizziness is a common chief complaint that often poses a diagnostic challenge. A 79-year-old man was initially misdiagnosed with peripheral vertigo based on normal neuroimaging but later developed altered consciousness and involuntary limb movements, ultimately revealing carbamazepine (CBZ) toxicity. This case highlights a critical diagnostic pitfall: prematurely attributing dizziness to peripheral vertigo without considering drug-induced syndromes. Although the potential role of concomitant amiodarone use remains uncertain, this case also underscores the importance of cautious CBZ dose escalation, serum level monitoring, and a thorough medication review. Recognizing CBZ toxicity as a mimicker of central vertigo is crucial for ensuring timely and accurate diagnosis, especially in elderly patients.

CureusVol. 17(2)
Keio University (JP), Teikyo University Chiba Medical Center (JP)
Openalex Percentile: Top 97%
Epilepsy research and treatment
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Overlooked Carbamazepine Toxicity: A Diagnostic Pitfall in an Elderly Patient With Dizziness — Katsuhiro Kobayashi, Takayuki Ando, et al. · Cureus (2025) | TGRS Research Map | TGRS