The Case of Congenital Combined Immunodeficiency with Severe Atopy: The Importance of Early Diagnosis and Features of Therapeutic Strategies

The article describes a case of congenital combined immunodeficiency with severe atopy – deficiency of the cytogenesis regulator (DOCK8) The article examines modern ideas about the role of DOCK8 protein in ensuring the basic functions of the immune system, the consequences of loss of function of DOCK8 protein, epidemiology, clinical manifestations, modern principles of diagnosis and treatment of DOCK8 deficiency.