Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci
Given these genes' significant role in T cell development and maturation, our work deepens our comprehension of autoimmune disease pathogenesis, suggesting potential treatment targets. In addition, our dataset provides a valuable resource for the investigation of immune-mediated diseases and gene regulatory mechanisms.
Authors
- Darren Plant (ORCID: https://orcid.org/0000-0003-1395-9344)
- Charlotte Wynn (ORCID: https://orcid.org/0000-0001-9850-4888)
- J. Scott Butler (ORCID: https://orcid.org/0000-0001-7428-2897)
- Antonios Frantzeskos (ORCID: https://orcid.org/0000-0002-2073-7750)
- John Bowes (ORCID: https://orcid.org/0000-0003-4659-031X)
- Ryan Malcolm Hum (ORCID: https://orcid.org/0000-0003-0801-6974)
- Magnus Rattray (ORCID: https://orcid.org/0000-0001-8196-5565)
- Anne C Barton (ORCID: https://orcid.org/0000-0003-3316-2527)
- Antony D. Adamson (ORCID: https://orcid.org/0000-0002-5408-0013)
- Stefano Rossi (ORCID: https://orcid.org/0000-0002-9022-4096)
- Ellie Richards (ORCID: https://orcid.org/0009-0004-3525-0066)
- Stephen Eyre (ORCID: https://orcid.org/0000-0002-1251-6974)
- Danyun Zhao (ORCID: https://orcid.org/0000-0003-0106-4658)
- Richard K. Grencis (ORCID: https://orcid.org/0000-0002-7592-0085)
- Paul J. Martin (ORCID: https://orcid.org/0000-0001-9051-1215)
- Pauline Ho (ORCID: https://orcid.org/0000-0001-5359-7195)
- Chuan Fu Yap (ORCID: https://orcid.org/0000-0001-5256-5642)
- James Ding (ORCID: https://orcid.org/0000-0001-7273-9646)
- Chenfu Shi (ORCID: https://orcid.org/0000-0002-3083-8416)
- Carlo Ferrazzano (ORCID: https://orcid.org/0000-0002-1161-3895)
- Gisela Orozco (ORCID: https://orcid.org/0000-0002-3479-0448)
- Muskan Gupta (ORCID: https://orcid.org/0009-0009-1420-3582)
- Khadijah Patel
Institutions
- Manchester Academic Health Science Centre (GB)
- Manchester Royal Infirmary (GB)
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
- Arthritis UK (GB)
- NIHR Manchester Biomedical Research Centre (GB)
Publication Details
- Journal
- Genome biology
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1186/s13059-025-03492-y
- Citations
- 7
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- University of Manchester
- Versus Arthritis
- Manchester Biomedical Research Centre
- Medical Research Council