An Intramolecular Minisci Reaction in Aqueous Media Using Langlois’ Reagent
A trifluoromethylpyridylation of unactivated alkenes in aqueous solution under open air is reported. This process allows the incorporation of trifluoromethyl and the construction of pyridines annulated to saturated cycles via an intramolecular Minisci reaction using Langlois' reagent (CF<sub>3</sub>SO<sub>2</sub>Na) as a trifluoromethyl source. Extrusion of air from the reaction is not required. A broad functional group tolerance is observed. A series of five-, six-, and seven-membered cycles are obtained, exhibiting great potential application in the preparation of diversified pyridines.
Authors
- Wengui Wang (ORCID: https://orcid.org/0000-0003-3702-6901)
- Shoufeng Wang (ORCID: https://orcid.org/0000-0002-5575-5772)
- Jing Li (ORCID: https://orcid.org/0000-0002-5627-4153)
Institutions
- University of Jinan (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1021/acs.joc.4c01652
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.79
Funders
- National Natural Science Foundation of China
- University of Jinan