Tau-tubulin kinase 2 restrains microtubule-depolymerizer KIF2A to support primary cilia growth
Together, our data imply that the regulation of KIF2A by TTBK2 represents an important mechanism governing cilia elongation and maintenance. Further, the requirement for concentrating TTBK2 activity to the mother centriole to initiate ciliogenesis can be under specific conditions bypassed, revealing TTBK2 recruitment-independent functions of its key partner, CEP164.
Authors
- Zdeněk Lánský (ORCID: https://orcid.org/0000-0001-8474-053X)
- Tereza Renzová (ORCID: https://orcid.org/0000-0003-3928-7195)
- David Vysloužil (ORCID: https://orcid.org/0000-0002-9080-2271)
- Lukáš Čajánek (ORCID: https://orcid.org/0000-0003-2914-8589)
- Lucia Binó
- Ondřej Bernatík (ORCID: https://orcid.org/0000-0002-2188-332X)
- Andrea Lacigová (ORCID: https://orcid.org/0009-0004-7001-4376)
- Eva Lánská
- Tereza Drahošová
Institutions
- Charles University (CZ)
- Masaryk University (CZ)
- Czech Academy of Sciences, Institute of Biotechnology (CZ)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1186/s12964-025-02072-8
- Citations
- 5
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 9.09
Funders
- Univerzita Karlova v Praze
- Přírodovědecká Fakulta, Univerzita Karlova
- European Commission
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Grantová Agentura České Republiky
- Akademie Věd České Republiky
- Central European Institute of Technology
- Masarykova Univerzita
- European Regional Development Fund