Electric Field Modulation on MoS₂ Nanoreactors for Enhanced Photodynamic Therapy of Severe Acute Pancreatitis

Severe acute pancreatitis (SAP) is one of the most common gastrointestinal emergencies in clinical practice. However, there are many limitations in clinical treatment, such as complicated processes with a long cycle and poor prognosis. As one of the emerging therapeutic methods in recent years, nanomaterial-mediated photodynamic therapy (PDT) has brought light to the treatment of disease. In this work, we design three morphologically controlled MoS2 nanoreactors for SAP photodynamic therapy. The hollow MoS2 (H-MoS2) nanoreactor possesses the highest electric field intensity and light absorption, resulting in the best therapeutic effects under 808 nm of irradiation. The amylase and lipase were reduced to one-third of the SAP, and the apoptosis rate of pancreatic acinar cells was reduced to one-half of that in the SAP. Our work opens a window for the construction of high-performance nanomedicine for SAP photodynamic therapy, especially in more inflammatory diseases.