Dual Role of α-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow
In summary, our study demonstrates the dual role of HPA activation and α-MSH secretion induced by colitis in the pathogenesis of IBD. These findings offer vital guidance for optimizing personalized treatment of IBD, emphasizing the importance of carefully managing the timing and dosage of α-MSH for its effective clinical application.
Authors
- Xiping Liao (ORCID: https://orcid.org/0009-0005-0675-6452)
- Hong Wei (ORCID: https://orcid.org/0000-0001-6069-1067)
- Hengqian Liu
- Qian Dai (ORCID: https://orcid.org/0000-0002-9164-9408)
- Hongli Zhou (ORCID: https://orcid.org/0000-0002-5561-2587)
- Xia Xie
- Yuan-Yuan Li (ORCID: https://orcid.org/0009-0006-8043-8900)
- Jianyun Zhou (ORCID: https://orcid.org/0000-0003-3545-5681)
- Wei Zhang (ORCID: https://orcid.org/0009-0003-5785-7363)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Army Medical University (CN)
- Chongqing University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/jir.s503621
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42