Immune Thrombocytopenia: Dexamethasone versus Prednisolone-Systemic Review and Meta-Analysis

Background: Immune thrombocytopenia (ITP) is an acquired disorder marked by destruction of platelets and suppression of their production, which may cause a range of bleeding symptoms.The use of dexamethasone versus prednisolone in managing immune thrombocytopenic purpura is still debatable.Consistent patterns and achievements can be demonstrated by systematic review.Objectives: To evaluate the effectiveness and safety of Dexamethasone in compare with prednisolone in treatment of ITP.Search method: We searched Embase database searched through Ovid interface from 1946 to 24/September/2024.The main search concepts are covering diagnosis (immune thrombocytopenia), intervention (steroids), with relevant synonyms for both concepts, and the RCTs filters.There were no restrictions for language, date of publication, or any other restrictions.Millions of hits (for intervention and RCTs filters) were identified, so one filter was added to involve non animals' studies, number of hits of RCTs filters was decreased, however still in millions.Then the search combined filters together ran again and 4611 hits were identified.