Promoting the transition from pyroptosis to apoptosis in endothelial cells: a novel approach to alleviate methylglyoxal-induced vascular damage
This study uncovers a novel mechanism through which MGO induces VEC damage, highlighting the therapeutic significance of the transition from pyroptosis to apoptosis in this process. These findings suggest potential therapeutic strategies for managing diabetic angiopathy. Furthermore, DT-13 emerges as a promising compound for therapeutic intervention, offering new possibilities for clinical applications.
Authors
- Hu Xu (ORCID: https://orcid.org/0000-0003-1198-0932)
- Xiaoru Zhang (ORCID: https://orcid.org/0000-0002-2251-3208)
- Xiuli Wang (ORCID: https://orcid.org/0000-0002-0867-1816)
- Mingqi Wang (ORCID: https://orcid.org/0000-0002-0434-9619)
- Lina Guo (ORCID: https://orcid.org/0000-0002-0620-0148)
- Yao Yang (ORCID: https://orcid.org/0000-0003-0386-0439)
- Ruqiang Yuan
Institutions
- Dalian Medical University (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1186/s12967-025-06195-x
- Citations
- 7
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 9.23
Funders
- National Natural Science Foundation of China
- Dalian Medical University