A novel therapeutic approach targeting PD-L1 in HNSCC and bone marrow-derived mesenchymal stem cells hampers pro-metastatic features in vitro: perspectives for blocking tumor-stroma communication and signaling
BM-MSCs recruited and educated by HNSCC cells support tumor cell aggressiveness via PD-L1. A novel rFab' anti-PD-L1 reduces HNSCC proliferation, migration and invasion and potentiates the cisplatin effect suggesting its potential to be conjugated with drugs for immuno-cytotoxic therapy.
Authors
- Maria Grazia Caprio (ORCID: https://orcid.org/0000-0003-0492-6911)
- Ylenia Ferrara (ORCID: https://orcid.org/0000-0002-1939-6653)
- Laura Cerchia (ORCID: https://orcid.org/0000-0002-7633-7932)
- Annamaria Sandomenico (ORCID: https://orcid.org/0000-0001-5255-3668)
- Debora Latino (ORCID: https://orcid.org/0000-0003-0757-8430)
- Angela Costagliola di Polidoro (ORCID: https://orcid.org/0000-0003-4089-104X)
- Annachiara Sarnella
- Antonella Zannetti (ORCID: https://orcid.org/0000-0002-6753-3659)
- Menotti Ruvo (ORCID: https://orcid.org/0000-0001-5997-756X)
- Angela Oliver (ORCID: https://orcid.org/0009-0004-4557-9922)
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- Institute of Biostructure and Bioimaging (IT)
- Institute for Experimental Endocrinology and Oncology (IT)
- Telethon Institute Of Genetics And Medicine (IT)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1186/s12964-025-02073-7
- Citations
- 8
- Primary Topic
- Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 8.36
Funders
- Ministero dell'Università e della Ricerca