FOXO3a/miR-4259-driven LDHA expression as a key mechanism of gemcitabine sensitivity in pancreatic ductal adenocarcinoma
Our results demonstrated that LDHA plays a critical role in cancer stemness and gemcitabine resistance of pancreatic cancer, and indicate that targeting the FOXO3a/miR-4259/LDHA pathway might serve as a new treatment for pancreatic cancer patients with a poor response to gemcitabine chemotherapy.
Authors
- Yen‐Hao Su (ORCID: https://orcid.org/0000-0001-8288-3772)
- Tung‐Wei Hsu
- Kuei‐Yen Tsai (ORCID: https://orcid.org/0000-0001-8592-6336)
- Alvin Chen (ORCID: https://orcid.org/0000-0002-6480-0467)
- Tzu‐Hsuan Wang (ORCID: https://orcid.org/0000-0002-6359-3427)
- Po‐Hsiang Liao (ORCID: https://orcid.org/0000-0002-4266-5428)
- Ching‐Feng Chiu (ORCID: https://orcid.org/0000-0001-5591-0288)
- George Kokotos (ORCID: https://orcid.org/0000-0003-3753-7082)
- Chih-Ming Su (ORCID: https://orcid.org/0000-0002-1035-4238)
- Wanyu Wang (ORCID: https://orcid.org/0000-0003-2500-4318)
- Hsin‐An Chen (ORCID: https://orcid.org/0009-0002-0784-126X)
- Cheng-Chin Kuo
Institutions
- Chung Yuan Christian University (TW)
- National Health Research Institutes (TW)
- National and Kapodistrian University of Athens (GR)
- Tzu Chi Foundation (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1186/s40170-025-00377-3
- Citations
- 1
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Science Council
- Academia Sinica
- Ministry of Education, India
- Taipei Medical University
- National Health Research Institutes
- National Cheng Kung University
- National Science and Technology Council
- Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare