Evaluation of vitamin D levels in young patients with primary hyperparathyroidism combined with thyroid pathology

Aim. To assess vitamin D levels in young patients with primary hyperparathyroidism (PHPT) combined with thyroid gland pathology. Materials and methods. A total of 48 patients with PHPT were studied from September 2021 to December 2023. The patients were divided into two groups: those with PHPT and those with primary hyperparathyroidism combined with thyroid pathology. Blood levels of parathyroid hormone (PTH), calcium, phosphorus, vitamin D, thyroid-stimulating hormone (TSH) and free thyroxine were measured. In addition, ultrasound and scintigraphy of the parathyroid and thyroid glands were performed. Results and discussion. . Patients with PHPT and thyroid pathology had lower calcium levels (2.49±0.07 mmol/L) and higher vitamin D levels (19.1±2.9 ng/mL) than patients with PHPT alone (2.71±0.1 mmol/L and 10.6±1.5 ng/ mL, respectively). These differences may be related to the compensatory function of the body in the presence of both conditions. Ultrasound showed differences in the degree of parathyroid hyperplasia between the two groups. Conclusion. Monitoring vitamin D and calcium levels is essential to accurately assess the condition of patients with PHPT, especially when combined with thyroid pathology. This will help to plan comprehensive treatment and reduce the risk of complications.